Dual responsive oligo(lysine)-modified Pluronic F127 hydrogels for drug release of 5-fluorouracil

Physicochemical characterization and drug release of thermosensitive hydrogels composed of a hyaluronic acid/pluronic f127 graft.

Pluronic F127 (PF127) is a copolymer which forms thermosensitive hydrogels. Hyaluronic acid (HA) was grafted to PF127 to form a new hydrogel matrix (HP) for delivery of cisplatin and carboplatin. The physicochemical properties and drug delivery of the graft were examined in this study. HP system (20% HP copolymer in water) exhibited a similar sol-gel transition temperature (28.3 degrees C) as P...

Temperature-responsive and degradable hyaluronic acid/Pluronic composite hydrogels for controlled release of human growth hormone.

Temperature-sensitive hyaluronic acid (HA) hydrogels were synthesized by photopolymerization of vinyl group modified HA in combination with acrylate group end-capped poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer (Pluronic F127). The synthesized HA/Pluronic composite hydrogels gradually collapsed with increasing temperature over the range of 5-40 degrees ...

Stabilization and Release Effects of Pluronic F127 in Protein Drug Delivery

In modern times, protein drugs have had an ever-increasing ability to efficiently combat disease in the human body, and delivery of polypeptide agents, whether insulin or interferons, to biological targets has thus become a task of great importance to doctors and patients alike. For this reason, it is the goal of many medical researchers to preserve the bioactivity of specific protein drugs and...

Mechanically Tough Pluronic F127/Laponite Nanocomposite Hydrogels from Covalently and Physically Cross-Linked Networks

Novel Quaternary ammonium modified-tragacanth gum hydrogels for drug delivery applications with antimicrobial activity and release kinetic study

New antimicrobial hydrogels were prepared via reaction of functionalized-Tragacanth Gum biopolymer by glycidyltrimethylammonium chloride (QTG) with acrylamide (AM). Characterization of the QTG hydrogels with AM (QTG-AM) was carried out by thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and 1HNMR. Swelling behaviour of the QTG hydrogels was investigated on the p...